Pediatric Fluconazole


This reference library was created for the community of providers who care for children with these illnesses. It was developed to assist clinicians in understanding, diagnosing and treating pediatric invasive fungal infections. The library links to important references within each category but is not meant to be comprehensive. 


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International Pediatric Fungal Network, Box 3499, Duke University Medical Center, Durham, NC 27710. USA.   Tel: 919-668-4847 Email:

Pharmacokinetics of fluconazole in pediatric patients. 

Brammer KW et al. Eur J Clin Microbiol Infect Dis. 1994 April; 325-329.

Efficacy of fluconazole prophylaxis for prevention of invasive fungal infection in extremely low birth weight infants

Aziz M et al. Pediatr Infect Dis J. 2010 Apr;29(4):352-6.

Invasive fungal infections in pediatric patients with hematologic malignancies receiving oral amphotericin B solution and early intravenous administration of fluconazole. 

Watanabe N et al. J Pediatr Hematol Oncol. 2011 May;33(4):270-5.

Impact of routine fluconazole prophylaxis for premature infants with birth weights of less than 1250 g in a developing country. 

Rueda K et al. Pediatr Infect Dis J. 2010 Nov;29(11):1050-2.

Fluconazole loading dose pharmacokinetics and safety in infants. 

Piper L et al. Pediatr Infect Dis J. 2011 May;30(5):375-8.

Fluconazole pharmacokinetics and safety in premature infants

Turner K et al. Curr Med Chem. 2012;19(27):4617-20.

Chemoprophylaxis of neonatal fungal infections in very low birthweight infants: efficacy and safety of fluconazole and nystatin

Blyth CC et al. J Paediatr Child Health. 2012 Sep;48(9):846-51.

Triazole use in the nursery: fluconazole, voriconazole, posaconazole, and ravuconazole. 

Watt K et al. Curr Drug Metab. 2013 Feb;14(2):193-202.

European survey on the use of prophylactic fluconazole in neonatal intensive care units. 

Kaguelidou F et al. Eur J Pediatr. 2012 Mar;171(3):439-45.

Targeted fluconazole prophylaxis for high-risk very low birth weight infants

Rolnitsky A et al. Eur J Pediatr. 2012 Oct;171(10):1481-7. Epub 2012 May 25.

Micafungin versus fluconazole for prophylaxis against fungal infections in premature infants.

Maede Y et al. Pediatr Int. 2013 Jun 17. doi: 10.1111/ped.12157. [Epub ahead of print]

Pharmacokinetics and safety of fluconazole in young infants supported with extracorporeal membrane oxygenation

Watt KM et al. Pediatr Infect Dis J. 2012 Oct;31(10):1042-7.